Kylie Chen

Bayesian phylogenetics with incomplete lineage tracing data

This paper introduces a Bayesian framework to improve phylogenetic inference from sparse lineage tracing data by modeling barcode loss, showing it enhances accuracy and recovers higher growth rates than standard filtering methods.

Single-cell phylodynamics reveal rapid late-stage colorectal cancer expansions

The paper uses single-cell whole-genome sequencing and Bayesian phylodynamic modeling to show colorectal tumors often originate decades before diagnosis and expand rapidly in the last two years.

Bayesian model-averaging of parametric coalescent models for phylodynamic inference

This paper introduces a Bayesian Model Averaging framework for phylodynamic inference that integrates multiple coalescent models to better capture demographic histories without pre-specifying a single model.