Débora Chantada

The paper uses single-cell whole-genome sequencing and Bayesian phylodynamic modeling to show colorectal tumors often originate decades before diagnosis and expand rapidly in the last two years.

SIEVE jointly infers somatic variants and cell phylogeny from scDNA-seq data, showing improved accuracy in both tasks compared to existing methods.

This study sequences single-cell mitochondrial genomes from colorectal cancer patients to investigate mtDNA heteroplasmy in normal and tumor cells.