Monica Vishnu Valecha

The paper uses single-cell whole-genome sequencing and Bayesian phylodynamic modeling to show colorectal tumors often originate decades before diagnosis and expand rapidly in the last two years.

DelSIEVE infers cell phylogeny and variants from scDNA-seq data, improving detection of deletions and evolutionary events compared to existing methods.

SIEVE jointly infers somatic variants and cell phylogeny from scDNA-seq data, showing improved accuracy in both tasks compared to existing methods.

This study compares genomic profiling of circulating tumor cells (CTCs) using three methods in metastatic colorectal cancer, finding differences in mutational burden and diversity estimates.

This study sequences single-cell mitochondrial genomes from colorectal cancer patients to investigate mtDNA heteroplasmy in normal and tumor cells.