Sonia Prado‐Lòpez

The paper uses single-cell whole-genome sequencing and Bayesian phylodynamic modeling to show colorectal tumors often originate decades before diagnosis and expand rapidly in the last two years.

SIEVE jointly infers somatic variants and cell phylogeny from scDNA-seq data, showing improved accuracy in both tasks compared to existing methods.

This study compares genomic profiling of circulating tumor cells (CTCs) using three methods in metastatic colorectal cancer, finding differences in mutational burden and diversity estimates.

This study sequences single-cell mitochondrial genomes from colorectal cancer patients to investigate mtDNA heteroplasmy in normal and tumor cells.

This study compares six single-cell whole-genome amplification methods using human cells, finding that REPLIg performs best in DNA yield and uniformity while Ampli1 shows fewer technical artifacts.