The PPR domain of mitochondrial RNA polymerase is a ribonuclease required for mtDNA replication
Yi Liu, Zhe Chen, Zongheng Wang, Katherine Delaney, Juanjie Tang, Mehdi Pirooznia, Duck‐Yeon Lee, Yuesheng Li, Hong Xu
This study identifies the PPR domain of POLRMT as an exoribonuclease essential for mtDNA replication and transcription proofreading in Drosophila and humans.
bioRxiv · Mar 12, 2021 · PreprintMolecular Biology