Zongheng Wang

Mitochondrial DNA removal is essential for sperm development and activity

This study shows that mitochondrial DNA removal is essential for sperm development and activity, revealing a novel exonuclease, ExoA, required for mtDNA elimination and preventing nuclear-mito imbalance.

A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

The paper identifies a transcriptional network regulating mitochondrial biogenesis in Drosophila by combining RNAi screening and ChIP-seq analysis, revealing key factors like CG1603 and YL-1.

The PPR domain of mitochondrial RNA polymerase is a ribonuclease required for mtDNA replication

This study identifies the PPR domain of POLRMT as an exoribonuclease essential for mtDNA replication and transcription proofreading in Drosophila and humans.

Developmentally-orchestrated mitochondrial processes prime the selective inheritance against harmful mitochondrial DNA mutations

The paper investigates mtDNA selective inheritance in Drosophila, showing that developmentally-orchestrated mitochondrial processes like fission and transcription enable purifying selection against harmful mutations.

Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila

The paper shows that a JNK-insulin-Myc signaling relay activates electron transport chain biogenesis, ensuring sufficient mtDNA in Drosophila eggs and limiting deleterious mtDNA mutations.