Hong Xu

The paper uses in situ imaging to show that mtDNA selection in Drosophila ovaries is driven by replication competition, not active elimination.

This study identifies a WYL family protein in Moraxellaceae that regulates both DNA damage response and anti-phage defense networks, enhancing understanding of bacterial immunity and antibiotic resistance.

This study shows that mitochondrial DNA removal is essential for sperm development and activity, revealing a novel exonuclease, ExoA, required for mtDNA elimination and preventing nuclear-mito imbalance.

The paper identifies a transcriptional network regulating mitochondrial biogenesis in Drosophila by combining RNAi screening and ChIP-seq analysis, revealing key factors like CG1603 and YL-1.

The paper identifies regulatory degeneration in Alzheimer's disease using RNA-seq data and suggests HDAC1 as a potential drug target.

The paper generates a high-confidence mitochondrial protein compendium in Dictyostelium discoideum using proteomic and computational methods, identifying 1082 proteins and highlighting unique features compared to other organisms.

This study identifies the PPR domain of POLRMT as an exoribonuclease essential for mtDNA replication and transcription proofreading in Drosophila and humans.

This study shows that disrupting mitochondrial electron transport chain (ETC) in Drosophila intestinal stem cells (ISCs) impairs their differentiation, likely through increased FOXO signaling.

The paper investigates mtDNA selective inheritance in Drosophila, showing that developmentally-orchestrated mitochondrial processes like fission and transcription enable purifying selection against harmful mutations.

The paper shows that a JNK-insulin-Myc signaling relay activates electron transport chain biogenesis, ensuring sufficient mtDNA in Drosophila eggs and limiting deleterious mtDNA mutations.