Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry
Matúš Vojtek, Jingchao Zhang, Juanjuan Sun, Man Zhang, Ian Chambers
This study shows that NANOG induces germline entry by repressing Otx2, while ESRRB cannot do so due to insufficient Otx2 repression, revealing a mechanism in PGC specification.
Stem Cell Reports · Dec 30, 2021Peer-reviewedDevelopmental Biology