Man Zhang

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

This study shows that TET protein deficiency in mouse ESCs leads to impaired somatic differentiation and accelerated germline entry.

Highly efficient generation of blastocyst-like structures from mouse totipotent blastomere-like cells

The paper demonstrates that TBLCs can efficiently generate blastocyst-like structures with 80% efficiency, outperforming EPSCs in blastoid formation.

Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry

This study shows that NANOG induces germline entry by repressing Otx2, while ESRRB cannot do so due to insufficient Otx2 repression, revealing a mechanism in PGC specification.

Whole-Genome Association Analyses of Sleep-disordered Breathing Phenotypes in the NHLBI TOPMed Program

The paper reports whole-genome association analyses of sleep-disordered breathing traits in the NHLBI TOPMed program, identifying rare and common variant associations.

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

The paper introduces BinomiRare, a test for rare variant association with binary outcomes in mixed models, showing it controls type 1 error in simulations and applies it to study genetic variants in disease traits.

Functional dissection of the enhancer repertoire in human embryonic stem cells

The paper identifies functional enhancers in human embryonic stem cells using a combination of chromatin immunoprecipitation and a massively parallel reporter assay, revealing novel enhancer classes and activity patterns.