Author

Jingchao Zhang

University of PennsylvaniaORCID 0000-0001-5289-6062Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jingchao Zhang1 paper · University of Pennsylvania

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Ian ChambersiD· 2 shared Matúš VojtekiD· 2 shared Abhyudai SinghiD· 1 shared Alison C. McGarveyiD· 1 shared Aoife O’FarrelliD· 1 shared Apurv SrivastaviD· 1 shared Arjun RajiD· 1 shared Bomyi LimiD· 1 shared

Activity by Year

2021-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Ian ChambersORCID

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 27, 2025

Direct recruitment of RNA Polymerase II by NANOG to activated target genes

Nicholas P. Mullin, Elisa Barbieri, Jingchao Zhang…·Ian Chambers

This study identifies a direct interaction between NANOG and RNA Polymerase II that regulates transcription and ESC self-renewal.

DOI 10.1101/2025.11.27.690710

𝕏 PostBluesky

BioengineeringbioRxivPreprintJun 27, 2025

Lineage memory shapes viral resistance barriers in human skin

Laura C. Van Eyndhoven, Grant Kinsler, Jingchao Zhang…·Arjun Raj

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

2 citations

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Molecular BiologybioRxivPreprintMar 17, 2025

Heterogeneous Sox2 transcriptional dynamics mediate pluripotency maintenance in mESCs in response to LIF signaling perturbations

Gaochen Jin, Emilia A. Leyes Porello, Jingchao Zhang, Bomyi Lim

This study investigates how LIF signaling perturbations affect Sox2 transcriptional dynamics in mESCs, revealing that reduced Sox2 expression, not complete loss, drives pluripotency loss.

1 citation

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Developmental BiologyStem Cell ReportsPeer-reviewedDec 30, 2021

Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry

Matúš Vojtek, Jingchao Zhang, Juanjuan Sun…·Ian Chambers

This study shows that NANOG induces germline entry by repressing Otx2, while ESRRB cannot do so due to insufficient Otx2 repression, revealing a mechanism in PGC specification.

9 citations

mousebulk RNA-seq

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