Nanoliter-scale selection of optimized bioengineered peptide antibiotics that rescue mice with bacterial lung infection
Nils Böhringer, Zerlina G. Wuisan, Michael Marner, I Dewa Made Kresna, Ute Mettal, Steven Schmitt, Silke Reiter, Yang Liu, Karina Brinkrolf, Oliver Rupp, Oliver Schwengers, Julia Findeisen, Susanne Herold, Ulrich Matt, Till F. Schäberle
This study uses a mutasynthetic library to identify optimized darobactin derivatives that effectively treat bacterial lung infections in mice.
bioRxiv · May 30, 2024 · PreprintMicrobiology