Yang Liu

Low-Density Lipoprotein Cholesterol and Cerebral Pericyte Dysfunction in Acute Ischemic Stroke: Clinical and Experimental Evidence

This study links LDL-C to cerebral pericyte dysfunction in acute ischemic stroke through clinical and experimental evidence, showing oxidative stress and type-I interferon signaling changes.

Tryptophan-Driven Metabolomic Shift in Acidobacteriaceae Reveals Phytohormones and Antifungal Metabolites

The paper identifies tryptophan-driven metabolic shifts in Acidobacteriaceae, revealing phytohormones and antifungal metabolites through metabolomic and genomic analysis.

Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain

This study shows BDNF supports pericyte and vascular health in aging brains by activating Akt signaling to increase PDGFRβ and CD13 expression.

Dual-domain Flower signaling coordinates extracellular vesicles-mediated fitness selection and cell-intrinsic survival in astrocytes

The paper identifies a dual-domain mechanism in the Flower protein that coordinates extracellular vesicle-mediated fitness selection and cell-intrinsic survival in astrocytes, with implications for Alzheimer's disease.

Gut miRNA regulates gut microbiome and Alzheimer pathology in App-knock-in mice

This study shows that gut miRNA depletion in App-knock-in mice alters microbiome composition, reduces Aβ load, and induces anxiety, suggesting miRNA manipulation could influence AD pathogenesis.

Nanoliter-scale selection of optimized bioengineered peptide antibiotics that rescue mice with bacterial lung infection

This study uses a mutasynthetic library to identify optimized darobactin derivatives that effectively treat bacterial lung infections in mice.

Modulation of Alzheimer's Disease Brain Pathology in Mice by Gut Bacterial Deletion: The Role of Il-17a and Microglial MyD88

This study shows that deleting gut bacteria reduces Alzheimer's pathology in mice by affecting Il-17a and microglial MyD88 signaling.

Deficiency of p38&α-MAPK in myeloid cells ameliorates symptoms and pathology of APP-transgenic AD mice

This study shows that deleting p38-MAPK in myeloid cells reduces Aβ levels and improves cognitive function in APP-transgenic AD mice.