DNA Demethylation is Dispensable for Venetoclax-HMA Synergy in Acute Myeloid Leukaemia
Aida Selimović-Pašić, Lisa Haglund, Maike Bensberg, Julia Goldmann, Sandra Hellberg, Colm E. Nestor
This study shows that DNA demethylation is not required for venetoclax-hypomethylating agent synergy in AML, as synergy correlates with DNA damage rather than demethylation.
bioRxiv · Apr 13, 2026 · PreprintCancer Biology