This study shows that DNA demethylation is not required for venetoclax-hypomethylating agent synergy in AML, as synergy correlates with DNA damage rather than demethylation.

bioRxiv · Apr 13, 2026 · PreprintCancer Biology

TRiXi: A Multi-Target Tandem Repeat-Based Method for Accurate Detection of X-Inactivation Skewing in Humans

Dóra Goldmann, Björn Gylemo, Maike Bensberg, Ingela Johansson, Svenja Löffert, Júlia Goldmann, Lisa Haglund, Magda Vítková, Janos Kondri, Sandra Hellberg, Engla Haglund, Shadi Jafari, Johnny Ludvigsson, Colm E. Nestor

TRiXi detects X-inactivation skewing in human DNA, revealing it as a common and stable epigenetic trait across multiple tissues and ages.

medRxiv · Nov 24, 2025 · PreprintGenetic & Genomic Medicine

A validated strategy to infer protein biomarkers from RNA-Seq by combining multiple mRNA splice variants and time-delay

Rasmus Magnusson, Olof Rundquist, Min Jung Kim, Sandra Hellberg, Chan Hyun Na, Mikael Benson, David Gómez-Cabrero, Ingrid Skelton Kockum, Jesper N. Tegner, Fredrik Piehl, Maja Jagodic, Johan Mellergård, Claudio Altafini, Jan Ernerudh, Maria Christina Jenmalm, , Mika Gustafsson

The paper develops a mathematical model combining mRNA splice variants and time-delay to predict protein abundance from RNA-Seq, improving biomarker discovery in immune diseases.

bioRxiv · Feb 21, 2020 · PreprintBioinformatics