Colm E. Nestor

The paper investigates age-related X chromosome inactivation (XCI) erosion in human females using bulk and single-cell datasets, finding age-dependent escape from XCI in specific genes.

This study shows that DNA demethylation is not required for venetoclax-hypomethylating agent synergy in AML, as synergy correlates with DNA damage rather than demethylation.

TRiXi detects X-inactivation skewing in human DNA, revealing it as a common and stable epigenetic trait across multiple tissues and ages.

The paper determines X-inactivation status of 380 X-linked genes across 30 tissues in non-mosaic X-inactivation females, revealing new insights into X-inactivation and its implications for sex-bias in human traits.

The paper develops a mathematical model combining mRNA splice variants and time-delay to predict protein abundance from RNA-Seq, improving biomarker discovery in immune diseases.

This study identifies and corrects a major source of error in DIP-seq data, revealing new biological insights and proposing methodological improvements.

LASSIM infers genome-wide gene regulatory networks using mechanistic ODE models, demonstrating its effectiveness in modeling Th2 differentiation with integrated data and siRNA experiments.