Intranucleolar Invasion of Cajal Body Remnants Suppresses Ribosomal Biogenesis in cis and Telomerase Functions in trans
Alexander Morris, Julia Hoopman, Vidhyadhar Nandana, Cameron Genxuan Lian, Emily Pochet, M Ledezma de Ruiz, Baihao Su, Andrey Efimov, Cynthia B. Myers, Yingda Tao, Luciano Saieva, Guoyu Lu, Erica A. Golemis, Livio Pellizzoni, Lü Chen
The paper shows that SMN inactivation causes CB components to invade the nucleolus, suppressing rRNA production and telomerase function through altered condensate interactions.
bioRxiv · Jul 17, 2026 · PreprintMolecular Biology