Lü Chen

Intranucleolar Invasion of Cajal Body Remnants Suppresses Ribosomal Biogenesis in cis and Telomerase Functions in trans

The paper shows that SMN inactivation causes CB components to invade the nucleolus, suppressing rRNA production and telomerase function through altered condensate interactions.

RNase H1 counteracts DNA damage and ameliorates SMN-dependent phenotypes in a Drosophila model of Spinal Muscular Atrophy

This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.

Clonal inactivation of telomerase promotes accelerated stem cell differentiation

This study shows that TERT inactivation accelerates stem cell differentiation and disrupts clone formation, independent of telomere elongation, and links TERT to MYC activity.

TGS1 controls snRNA 3' end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

This study shows TGS1 is essential for snRNA 3' end processing and its loss causes neurodegeneration, which can be mitigated by human TGS1 expression in model organisms.