Structural basis for the ATP-dependence of omegasome biogenesis by DFCP1
Mohit Misra, Zhicheng Cui, Marie‐Catherine Drigeard Desgarnier, Amin Godin, Deep Chatterjee, Y Zhang, Julia Pomirska, Laura Rodríguez de la Ballina, Karla Tapia, Sebastian Mathea, James H. Hurley, Kay Oliver Schink, Ivan Đikić, Harald Stenmark, Viola Nähse
This paper determines the crystal structures of DFCP1's ATPase domain with ADP and ATP analogues, revealing structural elements that regulate ATP hydrolysis and omegasome dynamics.
bioRxiv · May 30, 2026 · PreprintBiochemistry