Kay Oliver Schink

Structural basis for the ATP-dependence of omegasome biogenesis by DFCP1

This paper determines the crystal structures of DFCP1's ATPase domain with ADP and ATP analogues, revealing structural elements that regulate ATP hydrolysis and omegasome dynamics.

Critical role for Piccolo in Synaptic Vesicle Retrieval

This study shows Piccolo is essential for synaptic vesicle recycling through Pra1 and Rab5, linking its dysfunction to neurological disorders.

WDFY2 restrains matrix metalloprotease secretion and cell invasion by retention of VAMP3 in endosomal tubules

This study identifies WDFY2 as a tumor suppressor that restricts cell invasion by retaining VAMP3 in endosomal tubules, preventing MT1-MMP secretion and extracellular matrix degradation.

The PtdIns3P-binding protein Phafin2 escorts macropinosomes through the cortical actin cytoskeleton

This study identifies Phafin2 as a PtdIns3P-binding protein that facilitates macropinosome movement through the cortical actin cytoskeleton by regulating Filamin A.