Harald Stenmark

Structure and function of the DFCP1 membrane barrier responsible for ER microdomain organization in lysosome repair

This study determines the structure of DFCP1 and shows it forms a barrier that concentrates PI3P for lysosomal repair.

The kinesin-4 family member KIF27 regulates mitotic progression, cytokinesis and genome stability

This study identifies KIF27 as a regulator of mitotic progression, cytokinesis, and genome stability through its dynamic localization and functional roles in cell division.

ATG16L2 creates a VAIL-dedicated heterodimer with ATG16L1

This study identifies ATG16L2 as a specialized regulator of VAIL-selective ATG8 lipidation, forming a functional heterodimer with ATG16L1.

Structural basis for the ATP-dependence of omegasome biogenesis by DFCP1

This paper determines the crystal structures of DFCP1's ATPase domain with ADP and ATP analogues, revealing structural elements that regulate ATP hydrolysis and omegasome dynamics.

WDFY2 restrains matrix metalloprotease secretion and cell invasion by retention of VAMP3 in endosomal tubules

This study identifies WDFY2 as a tumor suppressor that restricts cell invasion by retaining VAMP3 in endosomal tubules, preventing MT1-MMP secretion and extracellular matrix degradation.

The PtdIns3P-binding protein Phafin2 escorts macropinosomes through the cortical actin cytoskeleton

This study identifies Phafin2 as a PtdIns3P-binding protein that facilitates macropinosome movement through the cortical actin cytoskeleton by regulating Filamin A.