Structural details of helix-mediated TDP-43 C-terminal domain multimerization
Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty, Patricia M. dos Passos, José F. Mercado Ortiz, Leanna Bai, Renjith Viswanathan, Julia Zaborowksy, Szu‐Huan Wang, Victoria Johnson, Lohany Dias Mamede, Amanda R. Titus, Yuna M. Ayala, Rodolfo Ghirlando, Jeetain Mittal, Nicolas Lux Fawzi
This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.
Nature Communications · Nov 26, 2025Peer-reviewedBiochemistry