Author

Jayakrishna Shenoy

Brown UniversityORCID 0000-0002-0360-645XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jeetain MittaliD· 2 shared Nicolas Lux FawziiD· 2 shared Priyesh MohantyiD· 2 shared Renjith ViswanathaniD· 2 shared Amanda R. Titus· 1 shared Azamat RizuaniD· 1 shared Busra OzguneyiD· 1 shared José F. Mercado Ortiz· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Jeetain MittalORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintDec 16, 2025

Site-specific methionine oxidation alters structure and phase separation of TDP-43 C-terminal domain

Busra Ozguney, Ryan Z Puterbaugh, Renjith Viswanathan…·Nicolas Lux Fawzi

This study shows methionine oxidation in TDP-43's C-terminal domain disrupts structure and phase separation through region-specific mechanisms.

2 citations

protein structurebiophysical modeling

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedNov 26, 2025

Structural details of helix-mediated TDP-43 C-terminal domain multimerization

Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty…·Nicolas Lux Fawzi

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

33 citationstop 1%

humanproteomics

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