Priyesh Mohanty

This paper develops a graph-based model to predict small-molecule partitioning into biomolecular condensates using existing experimental data and applies it to identify chemically diverse partitioners.

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

This paper investigates how the disordered C-terminal domain of TDP-43 interacts with RNA and identifies key residues and structural features that mediate RNA recognition and binding specificity.

This study shows methionine oxidation in TDP-43's C-terminal domain disrupts structure and phase separation through region-specific mechanisms.

This study shows RNA modulates FUS condensate assembly and aggregation through specific molecular interactions, affecting phase separation and aggregate formation.

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

This study uses multiscale simulations to investigate polyglutamine aggregation mechanisms and how the N17 flanking domain influences fibril polymorphism in Huntingtons disease.

This study uses atomistic simulations to analyze the conformational dynamics and interdomain interactions of full-length FUS during phase separation, revealing key electrostatic interactions and domain stability effects.

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

This study uses molecular dynamics simulations to show that transient interdomain interactions in Httex1 modulate its structural ensemble and self-assembly, contributing to aggregation in Huntington's disease.

This study uses molecular dynamics simulations to show RNA-binding stabilizes TDP-43 tandem RRMs and reduces conformational plasticity, preventing pathological aggregation.