Author

Amanda R. Titus

Saint Louis University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Lohany Dias Mamede· 2 shared Yuna M. AyalaiD· 2 shared Azamat RizuaniD· 1 shared Jaime Vaquer‐AliceaiD· 1 shared Jayakrishna ShenoyiD· 1 shared Jeetain MittaliD· 1 shared José F. Mercado Ortiz· 1 shared Julia Zaborowksy· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Lohany Dias Mamede

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Author profile →

2 papers

Recent·Most cited

Structural details of helix-mediated TDP-43 C-terminal domain multimerization

Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty, Patricia M. dos Passos, José F. Mercado Ortiz, Leanna Bai, Renjith Viswanathan, Julia Zaborowksy, Szu‐Huan Wang, Victoria Johnson, Lohany Dias Mamede, Amanda R. Titus, Yuna M. Ayala, Rodolfo Ghirlando, Jeetain Mittal, Nicolas Lux Fawzi

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

Nature Communications · Nov 26, 2025Peer-reviewedBiochemistry

TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction

Lohany Dias Mamede, Miwei Hu, Amanda R. Titus, Jaime Vaquer‐Alicea, Rachel L. French, Marc I. Diamond, Timothy M. Miller, Yuna M. Ayala

This study shows that TDP-43 aggregation through prion-like seeding impairs its autoregulation, leading to dysfunction and loss of function in cells.

bioRxiv · Feb 11, 2025 · PreprintCell Biology