Customizing the Structure of Minimal TIM Barrels to Craft Efficient De Novo Enzymes
Julian Beck, Benjamin J. Smith, Mark Kriegel, Niayesh Zarifi, Emily Freund, Ahana G. Harsha, Jan Hartmann, Roberto A. Chica, Birte Höcker
The paper designs de novo TIM barrels with structural lids to create active sites for enzymatic function, achieving high catalytic efficiency.
Nature Chemical Biology · Jun 15, 2026Peer-reviewedBiochemistry