Mark Kriegel

The paper designs de novo TIM barrels with structural lids to create active sites for enzymatic function, achieving high catalytic efficiency.

This study designs stabilized variants of dynamic periplasmic binding proteins by considering mutations compatible with both conformations, improving thermal stability without compromising ligand binding.

The paper identifies a new type of PETase from the marine Halopseudomonas lineage with unique active site features and high salt tolerance, proposing a new classification for PETases.