ASO-mediated knockdown of GPNMB in mutant-GRN and Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses
Rebecca L. Wallings, Drew A. Gillett, Hannah A. Staley, Savanna Mahn, Julian Mark, Noelle K. Neighbarger, Holly B. Kordasiewicz, Warren D. Hirst, Malú G. Tansey
This study shows that reducing GPNMB in progranulin-deficient myeloid cells impairs lysosomal function and immune responses, suggesting GPNMB is essential for maintaining immune homeostasis.
Molecular Neurodegeneration · Apr 8, 2025Peer-reviewedImmunology