Noelle K. Neighbarger

This study investigates how RGS10 modulates NFκB subunit transcription and inflammatory cytokine profiles in peritoneal macrophages through experimental stimulation and transcript analysis.

This study shows that reducing GPNMB in progranulin-deficient myeloid cells impairs lysosomal function and immune responses, suggesting GPNMB is essential for maintaining immune homeostasis.

The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

This study shows that the Alzheimer's protective PLCG2-P522R variant affects peripheral macrophage function differently in males and females.

This study investigates GPNMB upregulation and MITF dysregulation in progranulin-deficient macrophages, linking them to early-stage neurodegenerative disease mechanisms.

This study shows that LC injury modifies neuroinflammation in the ventral midbrain during DSS-induced colitis, highlighting the neuroprotective role of the locus coeruleus.

This study examines the gut-brain axis in a mouse colitis model, identifying immune activation, oxidative stress, and myelination disruptions in the brain linked to intestinal permeability.

This study shows that reducing mutant Lrrk2 in macrophages decreases lysosomal tubule formation and pro-inflammatory responses, suggesting potential therapeutic benefits for LRRK2-related Parkinson's but possible immune system side effects.