Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Leonardo Vinícius Monteiro de Assis, Lina Jegodzinski, Julica Inderhees, Sylvia J. Wowro, Juliana Marques Affonso, Isabel Heyde, Emelie Luise Fischer, Witigo V Schönfels, Andrea Schenk, Florian Roßner, Michael Schupp, Jens Uwe Marquardt, Münevver Demir, Henrik Oster
This study shows that hepatocyte circadian clocks regulate cholesterol metabolism and protect against MASH, with Bmal1 playing a specific role in this process.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedPathology