Ablation of the FACIT collagen XII disturbs musculoskeletal ECM organization and causes patella dislocation and myopathy
Mengjie Zhu, Fabian Metzen, Janina Betz, Mark Hopkinson, Juliane Heilig, Thomas Imhof, Anja Niehoff, David E. Birk, Yayoi Izu, Andrew A. Pitsillides, Janine Altmüller, Gudrun Schreiber, Mats Paulsson, Manuel Koch, Bent Brachvogel
This study shows that collagen XII deficiency in mice causes patella dislocation and myopathy, with altered gene expression in tenocytes and human patients showing similar patella instability.
bioRxiv · Dec 29, 2021 · PreprintGenetics