Differences in substrate engagement and Retinoblastoma protein (RB) binding of human KDM5A and KDM5B
Till Ruengeler, Egor A. Pavlenko, Fabian Basler, Juliane Renn, Farnusch Kaschani, Marie-Anne Derichs, Linda C. Zirden, Batool Shannan, Alexandra Hommel, Markus Kaiser, Alexander Roesch, Simon Poepsel
This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.
bioRxiv · May 2, 2026 · PreprintBiochemistry