Farnusch Kaschani

NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana

This study shows that NbRD21 protease regulates receptor-like kinase homeostasis in Nicotiana benthamiana by affecting their post-translational processing and endocytic recycling.

A membrane-anchored inhibitor of papain-like cysteine proteases promotes Pseudomonas root colonization

This study identifies Cpi1, a membrane-anchored protease inhibitor in Pseudomonas that inhibits plant PLCPs, enhancing bacterial root colonization by modulating immune responses.

Eliminating polyphenol oxidase from Nicotiana benthamiana improves recombinant protein yield and purity and facilitates native-state protein studies

This study shows that eliminating polyphenol oxidase in Nicotiana benthamiana improves recombinant protein yield, purity, and native-state integrity during extraction.

Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

Differences in substrate engagement and Retinoblastoma protein (RB) binding of human KDM5A and KDM5B

This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.

Selective proteasomal degradation from the Golgi apparatus membrane

The paper identifies a mechanism by which misfolded Golgi membrane proteins are ubiquitinated and degraded by the proteasome to prevent Golgi fragmentation.

TPS Proteins coordinate plant growth with sugar availability via the SnRK1 Kinase

This study identifies TPS5/6/7 as T6P sensors that inhibit SnRK1 activity to coordinate plant growth with sugar availability in Arabidopsis thaliana.

MTBP allosterically activates Cdk8-CycC kinase activity

The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.

Reactivity-based proteomics uncovers ATP-induced proteome restructuring

This study uses reactivity proteomics to analyze ATP-induced changes in Arabidopsis proteomes, revealing conformational shifts and metabolite-protein interactions.

Bacterial pathogen deploys iminosugar galactosyrin to manipulate plant glycobiology

This study identifies galactosyrin, an iminosugar produced by Pseudomonas syringae, which inhibits plant β-galactosidase and alters host glycobiology to aid infection.

Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability

This study shows that lack of AtMC1 catalytic activity causes autoimmunity in Arabidopsis, which depends on NLR stability and can be reversed by overexpressing SNIPER1.

Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast

The paper shows that the subtilase SBT5.2 cleaves flagellin's flg22 epitope, inactivating its immunogenicity and controlling immune responses in plants.

Extracellular plant subtilases dampen cold shock peptide elicitor levels

The paper shows that the plant subtilase SBT5.2a cleaves the bacterial cold-shock protein csp22, reducing its immunogenicity and pathogen growth.

A non-autonomous protein quality control mechanism targeting tau aggregate propagation

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.

TopBP1 utilises a bipartite GINS binding mode to support genome replication

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

Induced degradation of SNAP-fusion proteins

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate

The paper reports cryoEM structures of the Pex1/Pex6 ATPase complex from yeast, revealing how it translocates substrates through conformational changes and mechanical force propagation.

Proteome-wide Profiling of RNA-Binding Protein Responses to flg22 Reveals Novel Components of Plant Immunity

This study identifies flg22-responsive RNA-binding proteins in Arabidopsis, revealing their role in plant immunity and uncovering novel immune components.