Alexander Roesch

Differences in substrate engagement and Retinoblastoma protein (RB) binding of human KDM5A and KDM5B

This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.

Lactate-dependent metabolic rewiring is associated with CD163+ macrophage polarization in human pyelonephritis

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.