Glycomimetic Lysosome-targeting Chimeras (GLYTACs) for Degradation of Growth Factors and Growth Factor Receptors in Cancer Cells.
Julianna L. Follmar, Toshiki Tabuchi, Kamil Godula
This paper develops GLYTACs, which degrade extracellular growth factors and their receptors in cancer cells by targeting lysosomes, showing effectiveness against FGF2 and FGFRs in HeLa cells.
bioRxiv · Dec 30, 2025 · PreprintCancer Biology