Computational correction of cell-specific gene-independent effects in CRISPR-Cas9 essentiality screens: REStricted CUbic SplinEs with Mixed Models (RESCUE-MM)
Julie A. Dias, Shibing Deng, Vinícius Bonato
This paper introduces RESCUE-MM, a one-step method to correct gene-independent effects in CRISPR-Cas9 screens by integrating restricted cubic splines and mixed models, improving accuracy over two-step approaches.
bioRxiv · Oct 22, 2021 · PreprintBioinformatics