Author
University College DublinORCID 0000-0001-8614-7780Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Emma J. Doyle, Maeve Boyce, Sarah Buggle…·Eric Conway
The paper shows that pathogenic PR-DUB complex variants reduce H2AK119ub1 levels by stabilizing truncated ASXL1, leading to PRC2 displacement and H3K27me3 reduction, a phenotype shared across different chromatinopathies.
Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw…·Emma M. Kerr
This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.
Mihaela Ola, Caoimhe E. O’Brien, Aisling Y. Coughlan…·Geraldine Butler
The paper reports polymorphic centromere locations in Candida parapsilosis, showing natural movement between sites without significant DNA sequence changes.
Stephanie Braun‐Galleani, Julie A. Dias, Aisling Y. Coughlan…·Kenneth H. Wolfe
The paper sequenced K. phaffii isolates and analyzed meiotic recombination in a cross, finding lower recombination rates and centromere suppression compared to S. cerevisiae.
Alexander Douglass, Caoimhe E. O’Brien, Benjamin Offei…·Kenneth H. Wolfe
The paper introduces Coverage-versus-Length plots to assess de novo yeast genome assemblies, identifying contaminants and atypical scaffolds through coverage and length analysis.