Kenneth H. Wolfe

The paper identifies an evolutionary arms race between WHO endonucleases and their target site in the FBA1 gene in Torulaspora yeast, showing rapid sequence diversification to evade cleavage.

The paper examines centromere structure and location across nine yeast species, finding conserved chromosomal positions but diverse structures, suggesting in situ structural changes.

The paper identifies VLEs in two fungal phyla, suggesting they were present in the common ancestor of terrestrial fungi around 650 Mya.

The paper defines the pangenome of 372 Candida parapsilosis isolates, revealing low genetic diversity and identifying gene content variations associated with nitrogen metabolism.

The paper identifies 45 new zymocin-like toxin genes in budding yeasts, showing their diversity and suggesting VLEs have been parasitic for over 300 million years.

The paper identifies zymocin-like toxin gene clusters in filamentous fungi, showing their evolutionary origin and horizontal transfer in mushrooms.

The paper identifies copy number variations in fluconazole resistance genes in Candida parapsilosis isolates using whole-genome sequencing and GWAS.

This study identifies that resistance to miltefosine in Candida parapsilosis arises from RTA3 gene amplification or flippase inactivation, altering plasma membrane lipid asymmetry.

The paper reports polymorphic centromere locations in Candida parapsilosis, showing natural movement between sites without significant DNA sequence changes.

The paper sequenced K. phaffii isolates and analyzed meiotic recombination in a cross, finding lower recombination rates and centromere suppression compared to S. cerevisiae.

The paper introduces Coverage-versus-Length plots to assess de novo yeast genome assemblies, identifying contaminants and atypical scaffolds through coverage and length analysis.

The paper reconstructs the first genome-scale metabolic model for Zygosaccharomyces parabailii, demonstrating its potential for metabolic engineering and industrial applications.