A modular platform for on-demand vaccine self-assembly enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens
Kevin B. Weyant, Julie Liao, Mariela Rivera-De Jesus, Thapakorn Jaroentomeechai, Tyler D. Moeller, Steven A. Hoang-Phou, Sukumar Pal, Sean F. Gilmore, Riya Singh, David A. Putnam, Christopher P. Locher, Luis M. de la Maza, Matthew A. Coleman, Matthew P. DeLisa
This paper introduces AddVax, a method to decorate bacterial outer membrane vesicles with biotinylated antigens to create vaccines, showing strong immune responses in mice.
bioRxiv · Aug 24, 2021 · PreprintSynthetic Biology