Mimicking of tau hyperphosphorylation in GABAergic motoneurons of C. elegans induces severe peripheral and neuronal alterations
Audrey Labarre, Emilien Schramm, Julie Pilliod, Samuel Boyer, Marianne Lapointe, Claudia Maios, Nicole M. Leclerc, J. Alex Parker
This study shows that overexpressing tau variants in C. elegans motor neurons causes neuronal and peripheral defects, suggesting tau dysfunction disrupts cell-cell communication.
bioRxiv · Jul 4, 2023 · PreprintNeuroscience