A workflow combining single-cell CRISPRi screening and a Sparse supervised autoencoder neural network to detect subtle transcriptomic perturbations induced by lncRNA Knock-Down
Marin Truchi, Caroline Lacoux, Cyprien Gille, Julien Fassy, Virginie Magnone, Rafael Lopez-Goncalvez, Cédric Girard-Riboulleau, Iris Manosalva, Marine Gautier‐Isola, Kévin Lebrigand, Pascal Barbry, Salvatore Spicuglia, Georges Vassaux, Roger Rezzonico, Michel Barlaud, Bernard P. Mari
The paper develops a Sparse supervised autoencoder to detect subtle transcriptomic changes from CRISPRi screens of lncRNAs in lung cancer cells under hypoxia.
Frontiers in Bioinformatics · Mar 4, 2024Peer-reviewedBioinformatics