Bernard P. Mari

Imaging-based spatial isoform transcriptomics resolves transcript diversity at cellular and subcellular resolution

The paper introduces iSiT, an imaging-based spatial isoform transcriptomics method, and demonstrates its application in the mouse brain to study transcript isoform diversity at cellular and subcellular resolution.

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

This study identifies AETA peptide as a novel contributor to synaptic dysfunction in Alzheimer's disease, particularly in females, through post-mortem analysis and a mouse model.

Single-cell transcriptomics reveals a differential response of human bronchial epithelial cell-types to cadmium chloride

The paper uses scRNA-seq to analyze the response of human bronchial epithelial cell types to CdCl2, revealing cell-type-specific transcriptional changes.

miR-210 locus deletion disrupts cellular homeostasis; an integrated genetic study

This study examines the effects of miR-210 locus deletion on cellular homeostasis in human and mouse cells, revealing deregulation of neighboring genes and unexpected lack of miR-210 target enrichment.

A workflow combining single-cell CRISPRi screening and a Sparse supervised autoencoder neural network to detect subtle transcriptomic perturbations induced by lncRNA Knock-Down

The paper develops a Sparse supervised autoencoder to detect subtle transcriptomic changes from CRISPRi screens of lncRNAs in lung cancer cells under hypoxia.

A critical role for miR-142 in alveolar epithelial lineage formation

This study identifies miR-142's role in regulating alveolar epithelial cell lineage formation through interactions with the glucocorticoid and p300 signaling pathways.

A smooth muscle-like niche facilitates lung epithelial regeneration

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.

Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases

This study identifies DNM3OS as a key regulator of fibroblast activation via miRNAs, offering a therapeutic target for fibrotic diseases like IPF.