Microbial metabolite p-cresol associates with constipation in adults with high-functioning autism spectrum disorder and induces constipation-like symptoms in mice
Narjis Kraïmi, David Fabregat‐Safont, Juliette Canaguier, Geoffroy Mallaret, Susana Barbosa, Julie Z. Brouillet, Florian Lejuste, Alexandru Gaman, Jean-Romain Richard, Chema Sahnoun Derbel, Anouck Amestoy, Marion Leboyer, Óscar J. Pozo, Laëtitia Davidovic
This study links elevated serum p-cresol levels to constipation in adults with high-functioning autism spectrum disorder and shows p-cresol induces constipation-like symptoms in mice.
Scientific Reports · Sep 28, 2026Peer-reviewedMicrobiology