Nicotine in adolescence freezes dopamine circuits in an immature state
Lauren M. Reynolds, Aylin Gulmez, Sophie L. Fayad, Renan Costa Campos, Daiana Rigoni, Claire Nguyen, Tinaïg Le Borgne, Thomas Topilko, Domitille Rajot, Clara Franco, Fabio Marti, Nicolas Heck, Alexandre Mourot, Nicolas Renier, Jacques Barik, Philippe Fauré
This study shows that adolescent nicotine exposure disrupts dopamine circuit development, leading to adult vulnerability to nicotine, which can be reversed by restoring dopamine pathway balance.
bioRxiv · Oct 28, 2023 · PreprintNeuroscience