Multilayered molecular and cellular mechanisms underlying intestinal epithelial regeneration
Dong Woo Seo, Seungsoo Kim, Hoibin Jeong, Mi Hyeon Cho, Min-Goo Lee, Jea Hwa Jang, Jun-Seok Lee, Sang-Hyun Choi, Dong‐Hoon Kim, Jungmin Choi, Yong Taek Jeong
This study identifies Hedgehog signaling as a key driver of intestinal stem cell regeneration by promoting the emergence of new Lgr5+ stem cells from non-Lgr5+ clones, distinct from existing self-renewal and dedifferentiation models.
bioRxiv · Jul 20, 2025 · PreprintCell Biology