Cell BiologybioRxivPreprint
Multilayered molecular and cellular mechanisms underlying intestinal epithelial regeneration
Dong Woo Seo, Seungsoo Kim, Hoibin Jeong…·Yong Taek Jeong
This study identifies Hedgehog signaling as a key driver of intestinal stem cell regeneration by promoting the emergence of new Lgr5+ stem cells from non-Lgr5+ clones, distinct from existing self-renewal and dedifferentiation models.