Targeting BMI1 and MCL1 for Lung Adenocarcinoma Treatment
Erh-Hsuan Lin, Chiung-Fang Hsu, Yi-Hua Jan, Tsung-Hsien Lin, Hsiang-Yi Chang, Chun-Ming Cheng, Hui-Jan Hsu, Wei-Wei Chen, Bo-Hung Chen, Hsing-Fang Tsai, Jung-Jung Li, Chi-Ying Huang, Shih-Hsien Chuang, Jia-Ming Chang, Michael Hsiao, Cheng-Wen Wu
This study identifies BMI1 and MCL1 as key drivers of lung adenocarcinoma progression and demonstrates that targeting these proteins with a novel small-molecule inhibitor suppresses tumor growth in preclinical models.
bioRxiv · Oct 22, 2018 · PreprintCancer Biology