Reinvestigating the role of ERK5: kinase activity is not required for cellular immune response or proliferation
Emme C.K. Lin, Christopher A. Amantea, Tyzoon K. Nomanbhoy, Helge Weissig, Junichi Ishiyama, Yi Hu, Shyama Sidique, Bei Li, John W. Kozarich, Jonathan S. Rosenblum
This study identifies that ERK5 kinase inhibitors lack anti-inflammatory and anti-proliferative effects, suggesting previously observed effects are due to off-target bromodomain inhibition.
bioRxiv · Jul 26, 2016Immunology