Wynand Paul Roos

HIPK2 regulates homology-directed DNA repair and PARP inhibitor sensitivity

This study identifies HIPK2's role in HR repair and PARPi sensitivity by regulating BRCA1 stability, suggesting HIPK2 inhibition as a therapeutic strategy for BRCA1-proficient cancers.

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response Proteins

This study identifies that rAAV toxicity in dividing cells results from depletion of PARP1 and other DNA damage response proteins, leading to replication stress and cell death.

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint

This study shows that DNA polymerase beta modulates the PARG-mediated replication checkpoint in HNSCC, and combining PARG and ATR/CHK1 inhibitors overcomes resistance.

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage

The paper evaluates WWE and macrodomain proteins as PAR probes in live cells and shows unique PAR dynamics that can modulate the DNA damage response.