Ultraviolet B Induces Cutaneous Lupus Erythematosus by Triggering a Ribotoxic-Stress-Response-Dependent MIF-p38 Feedback Loop in Keratinocytes
Chipeng Guo, Siweier Luo, Jigang Luo, Siyao Lu, Xiaomei You, Junlin Cao, Yong Du, Haoran Lv, Hanzhi Liang, Le Wang, Liangchun Wang, Tao Liu, Yiming Zhou
This study identifies a UVB-induced MIF-p38 feedback loop in lupus keratinocytes that drives cutaneous lupus erythematosus and shows a microneedle patch targeting MIF can alleviate skin lesions.
Cell Death and Disease · Feb 2, 2026Peer-reviewedImmunology