Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions
Weiting Zhang, Karl Petri, Junyan Ma, Hyunho Lee, Chia‐Lun Tsai, J. Keith Joung, Jing-Ruey Joanna Yeh
This study identifies pegRNA misfolding as a factor limiting CRISPR prime editing efficiency and shows refolding and point mutations can significantly improve it in zebrafish embryos.
eLife · Jun 7, 2024Peer-reviewedGenomics